-------------------------------------------------------------------- COLLOQUIUM OF THE COMPUTATIONAL MATERIALS SCIENCE CENTER AND THE SCHOOL OF PHYSICS, ASTRONOMY, & COMPUTATIONAL SCIENCES (CSI 898-Sec 001) -------------------------------------------------------------------- Blood Flow and Wall Mechanics of Brain Aneurysms Juan Cebral Department of Bioengeneering, George Mason University, Fairfax, VA Because unruptured cerebral aneurysms have high incidence but low rupture risk, and are being more frequently detected with non-invasive imaging, clinicians often need to decide whether to conservatively observe or immediately treat these aneurysms. Today clinical decisions are mostly driven by aneurysm size and location. Consideration are also given to shape irregularity, patient's gender and age, general health, familiy history, history of hemorrhage from another aneurysm, and difficulty of the intervention (surgical or endovascular). However, it is well known that many small aneurysms do rupture. Therefore, it is important to identify other independent parameters that can help evaluate unruptured aneurysms. Hemodynamics is thought to be a mayor player in the mechanisms responsible for aneurysm enlargement and subsequent rupture. Therefore, we are conducting computational studies using patient-specific models to identify flow conditions associated with aneurysm wall failure. In this talk I will describe these studies, in particular current investigations aiming at relating hemodynamic conditions with the structural status of the aneurysm wall and its mechanical behavior. February 23, 2015 4:30 pm Exploratory Hall, room 3301, Fairfax Campus Refreshments will be served at 4:15 PM. ---------------------------------------------------------------------- Find the schedule at http://www.cmasc.gmu.edu/seminars.htm